تفاعل #79512

معادلة التفاعل

1-ethyl-3-pyrrolecarboxylic acid

β-alanine ethyl ester hydrochloride

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

triethylamine

→

Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added dropwise under ice cooling
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 2.5 hours

الإجراء التجريبي

Into a suspension of 3.33 g (23.9 mmol) of 1-ethyl-3-pyrrolecarboxylic acid, 4.41 g (28.7 mmol) of β-alanine ethyl ester hydrochloride and 5.50 g (28.7 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride in 40 ml of methylene chloride, 4.0 ml (28.7 mmol) of triethylamine were added dropwise under ice cooling and stirring. The reaction mixture was stirred at room temperature for 2.5 hours.

المصدر