تفاعل #794571

معادلة التفاعل

Intermediate 47

Benzyl (cis-3-hydroxycyclobutyl)carbamate

p-toluenesulfonyl chloride

triethylamine

→

crude product

المردود 123.1%

cis-3-(((benzyloxy)carbonyl)amino)cyclobutyl 4-methylbenzenesulfonate

المردود 123.1%

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىReaction mixture
2. 2
   غسيلwashed with saturated NaHCO3 solution
3. 3
   تجفيفOrganic layer was dried over sodium sulfate

الإجراء التجريبي

A solution of Intermediate 47 (0.67 g, 3.03 mmol), p-toluenesulfonyl chloride (Sigma Aldrich, 1.155 g, 6.06 mmol), triethylamine (Aldrich, 1.688 ml. 12.11 mmol) in DCM (6.06 ml) was stirred at room temperature overnight. Reaction mixture was diluted with DCM and washed with saturated NaHCO3 solution. Organic layer was dried over sodium sulfate to provide 1.4 g crude product upon rotovap. Material was advanced to next step before further purification.

المصدر