تفاعل #79429

معادلة التفاعل

5-(4-(4-phenoxyphenylamino)-quinolin-7-yl)furan-2-carbaldehyde

2-(methanesulphonyl)ethylamine

→

(4-Phenoxyphenyl)-(7-(5-(2-(methanesulphonyl)ethylaminomethyl)furan-2-yl)-quinolin-4-yl)amine

ظروف التفاعل

المعالجة

1. 1
   أخرىAcidification with acetic acid (0.5 ml) followed by purification
2. 2
   غسيلeluting with methanol-ammonia (9:1), concentration and trituration with diethylether
3. 3
   أخرىafforded an off-white solid

الإجراء التجريبي

5-(4-(4-phenoxyphenylamino)-quinolin-7-yl)furan-2-carbaldehyde (0.05 g) was reacted with 2-(methanesulphonyl)ethylamine (0.075 g) according to procedure D. Acidification with acetic acid (0.5 ml) followed by purification using a ion-exchange (SCX) Bond Elut™ cartridge, eluting with methanol-ammonia (9:1), concentration and trituration with diethylether afforded an off-white solid; δH [2H6]DMSO 8.44 (1H, d), 8.41 (1H, d), 8.11 (1H, s), 7.85 (1H, d), 7.44-7.35 (4H, m), 7.18-7.03 (6H, m), 6.79 (1H, d), 6.47 (1H, d), 3.82 (2H, s), 3.01 (2H, t); m/z 514 (M+1)+.

المصدر