تفاعل #79417

معادلة التفاعل

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan

→

(6-(5-(1,3-Dioxolan-2-yl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

المذيبات

dioxan

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was evaporated
2. 2
   ترشيحThis was then filtered through Celite®
3. 3
   أخرىthe solvent evaporated
4. 4
   أخرىThe gummy residue was then triturated with hexane giving a beige solid (1.74 g)

الإجراء التجريبي

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine (1.85 g) and 5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan (3.82 g) in dioxan (40 ml) were reacted together as in Procedure B. The mixture was evaporated and the residue suspended in dichloromethane. This was then filtered through Celite® and the solvent evaporated. The gummy residue was then triturated with hexane giving a beige solid (1.74 g); m/z 485 (M+1)+.

المصدر