تفاعل #79415

معادلة التفاعل

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine

5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan

→

(6-(5-(1,3-Dioxolan-2-yl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine

المذيبات

dioxan

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was evaporated
2. 2
   ترشيحThis was then filtered through celite
3. 3
   أخرىthe solvent evaporated
4. 4
   أخرىThe gummy residue was then triturated with hexane giving a beige solid (1.21 g)

الإجراء التجريبي

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine (1.82 g) and 5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan (3.75 g) in dioxan (40 ml) were reacted together as in Procedure B. The mixture was evaporated and the residue suspended in dichloromethane. This was then filtered through celite and the solvent evaporated. The gummy residue was then triturated with hexane giving a beige solid (1.21 g); m/z 485 (M+1)+.

المصدر