تفاعل #79408

معادلة التفاعل

(1-benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)-amine

2-(tributylstannyl)-5-(1,3-dioxolan-2-yl)-furan

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title compound

(1-Benzyl-1H-indazol-5-yl)-(6-(5-(1,3-dioxolan-2-yl)-furan-2-yl)-quinazolin-4-yl)-amine

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىPrepared
2. 2
   أخرىThe solvent was removed in vacuo
3. 3
   أخرىthe residue chromatographed on silica

الإجراء التجريبي

Prepared according to Procedure B from (1-benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)-amine (4.3 g), 2-(tributylstannyl)-5-(1,3-dioxolan-2-yl)-furan (J. Chem. Soc., Chem Commun., (1988), 560) (10 g) and 1,4-bis(diphenylphosphino) palladium (II) chloride (1 g) in dioxane. The solvent was removed in vacuo and the residue chromatographed on silica. Subsequent trituration gave the title compound δH [2H6]-DMSO 10.13 (1H, s), 8.85 (1H, s), 8.54 (1H, s), 8.20 (3H, m), 7.80 (3H, m), 7.30 (5H, m), 7.13 (1H, d), 6.79 (1H, d), 6.04 (1H, s), 5.71 (2H, s), 4.15 (4H, m).

المصدر