تفاعل #79405

معادلة التفاعل

(4-Phenoxyphenyl)-(7-iodo-quinolin-4-yl)amine

(tributylstannyl)-5-(1,3-dioxolan-2-yl)-furan

→

solid

المردود 68.1%

(4-Phenoxyphenyl)-(7-(5-(1,3-dioxolan-2-yl)furan-2-yl)-quinolin-4-yl)amine

المردود 68.1%

المذيبات

dimethylacetamide

ظروف التفاعل

المعالجة

1. 1
   أخرىPurification via column chromatography
2. 2
   غسيلeluting with ethyl acetate

الإجراء التجريبي

(4-Phenoxyphenyl)-(7-iodo-quinolin-4-yl)amine (2 g) was treated with 2-to (tributylstannyl)-5-(1,3-dioxolan-2-yl)-furan (2.16 g) and tetrakis (triphenylphosphine) palladium (0) (0.26 g) in dimethylacetamide (20 ml) in accordance with Procedure B. Purification via column chromatography, eluting with ethyl acetate, followed by trituration with diethylether afforded a yellow solid (1.4 g); δH [2H6]DMSO 9.10 (1H, s), 8.45 (2H, m), 8.13 (1H, s), 7.96 (1H, d), 7.41 (4H, m), 7.22 (1H, d), 7.20-7.03 (5H, m), 6.83 (1H, d), 6.75 (1H, d), 6.02 (1H, s), 4.13 (2H, m), 4.01 (2H, m); m/z 451 (M+1)+.

المصدر