تفاعل #79395

ord-406f1e00518743a59f9aea8c3f84ac66

معادلة التفاعل

Cl.Fc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1I
(1-benzyl-1H-indazol-5-yl)-(6-iodo-7-fluoro-quinazolin-4-yl)-amine hydrochloride
CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1ccc(C2OCCO2)o1
5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)furan
Fc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1-c1ccc(C2OCCO2)o1
(1-Benzyl-1H-indazol-5-yl)-(6-(5-(1,3-dioxolan-2-yl)-furan-2-yl)-7-fluoro-quinazolin-4-yl)-amine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىPrepared

الإجراء التجريبي

Prepared according to Procedure B from (1-benzyl-1H-indazol-5-yl)-(6-iodo-7-fluoro-quinazolin-4-yl)-amine hydrochloride and 5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)furan. δ1H NMR (400 MHz, DMSO-d6) δ 10.27(s, 1H), 8.89(d, 1H), 8.46(s, 1H), 8.1(d, 2H), 7.69(d, 1H), 7.61(m, 2H), 7.26(m, 5H), 6.96(m, 1H), 6.74(d, 1H), 6.01 (s, 1H), 5.65(s, 2H), 4.09(m, 2H), 3.96(m, 2H). ESI-MS m/z 506(M−1).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06713485B2uspto-grants-2004_03