تفاعل #792145

معادلة التفاعل

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

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final compound

المردود 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

المردود 84.7%

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   أخرىwas conducted at atmospheric pressure room temperature until the starting material
2. 2
   ترشيحThe catalyst was filtered
3. 3
   أخرىthe crude was purified by chromatography on silica gel (25% EtOAc/hexane)

الإجراء التجريبي

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

المصدر