تفاعل #792143

معادلة التفاعل

(E)-1-(2-hydroxy-4,5-dimethylphenyl)-3-(pyridine-2-yl)prop-2-en-1-one

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final compound

المردود 49.2%

1-(2-hydroxy-4,5-dimethylphenyl)-3-(pyridine-2-yl)propan-1-one

المردود 49.2%

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe catalyst was filtered off
2. 2
   أخرىThe crude product was purified by chromatography on silica gel (20% EtOAc/hexane)

الإجراء التجريبي

In a 250 ml round-bottom flask, (E)-1-(2-hydroxy-4,5-dimethylphenyl)-3-(pyridine-2-yl)prop-2-en-1-one (1.17 g, 4.62 mmol) and 0.18 g of 10% Pd/C were mixed together in wet EtOAc. Hydrogenation was conducted at atmospheric pressure, then the catalyst was filtered off. The crude product was purified by chromatography on silica gel (20% EtOAc/hexane) to provide 0.58 g (47.7%) of final compound.

المصدر