تفاعل #792140

معادلة التفاعل

sodium hydroxide

triazole

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane

N-methyl-2-pyrrolidon

ammonium chloride

→

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture extracted with MTBE
2. 2
   غسيلwashed with an aqueous solution of lithium chloride
3. 3
   أخرىThe crude residue was purified by recrystallization in diisopropylether

الإجراء التجريبي

To 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane (216.0 g, 0.63 mol) dissolved in N-methyl-2-pyrrolidon (2 L) was added sodium hydroxide (62.87 g, 1.57 mol) and triazole (217.1 g, 3.14 mol) at room temperature. The mixture was then stirred for 12 hours at 140° C. A solution of ammonium chloride and ice water was then added, the mixture extracted with MTBE and washed with an aqueous solution of lithium chloride. The crude residue was purified by recrystallization in diisopropylether to give 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol compound as a colorless solid (127.0 g, 51%; m.p.=140-142° C.).

المصدر