تفاعل #79072

معادلة التفاعل

7-amino-4-methylthiopyrido[4,3-d]pyrimidine

4-bromoaniline

→

7-amino-4-(4-bromoanilino)pyrido[4,3-d]pyrimidine

المردود 46.5%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting product is chromatographed on silica gel (10-15% EtOH/EtOAc)

الإجراء التجريبي

A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (261 mg, 1.36 mmole) and 4-bromoaniline (1.00 g, 5.81 mmole) is stirred under N2 at 200° C. for 15 min. The resulting product is chromatographed on silica gel (10-15% EtOH/EtOAc) to give 7-amino-4-(4-bromoanilino)pyrido[4,3-d]pyrimidine (200 mg, 46%) as a pale yellow solid. 1H NMR (DMSO) δ 9.88 (1H, brs), 9.34 (1H, s), 8. 40 (1H, s), 7.83 (2H, d, J=8.8 Hz) 7.55 (2H, d, J=8.8 Hz), 6.64 (2H, brs), 6.44 (1H, s).

المصدر