تفاعل #79068

معادلة التفاعل

NaHCO3

7-amino-4-methylthiopyrido[4,3-d]pyrimidine

2-nitroaniline

HCl

→

7-amino-4-(2-nitroanilino)pyrido[4,3-d]pyrimidine

المردود 33.3%

المذيبات

MeOH CHCl3

ظروف التفاعل

المعالجة

1. 1
   أخرىdried onto silica gel
2. 2
   أخرىchromatographed over silica gel (2-4% MeOH/CH2Cl2)

الإجراء التجريبي

A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (220 mg, 1.15 mmole) and 2-nitroaniline (2.00 g, 14.5 mmole) is heated to 100° C., then excess dry HCl gas is added to the hot stirred solution, and the mixture stirred at 160° C. for 20 min. The resulting product is neutralized with excess NaHCO3, dissolved in MeOH/CHCl3, dried onto silica gel and chromatographed over silica gel (2-4% MeOH/CH2Cl2) to give 7-amino-4-(2-nitroanilino)pyrido[4,3-d]pyrimidine (108 mg, 33%) as a yellow brown solid. 1H NMR (DMSO) δ 10.40 (1H, brs), 9.24 (1H, brs), 8.20 (1H, brs), 8.12 (1H, brs), 8.01 (2H, brs), 7.75 (1H, brs), 6.70 (2H, brs), 6.43 (1H, brs).

المصدر