تفاعل #79064

معادلة التفاعل

7-amino-4-methylthiopyrido[4,3-d]pyrimidine

o-anisidine

→

7-amino-4-(2-methoxyanilino)pyrido[4,3-d]pyrimidine

المردود 47.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting product is chromatographed over silica gel (5% EtOH/EtOAc)

الإجراء التجريبي

A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (227 mg, 1.18 mmole) and o-anisidine (1.00 mL, 8.87 mmol) is stirred under N2 at 180° C. for 2.5 h. The resulting product is chromatographed over silica gel (5% EtOH/EtOAc) to give 7-amino-4-(2-methoxyanilino)pyrido[4,3-d]pyrimidine (147 mg, 47%) as a yellow solid. 1H NMR (DMSO) δ 9.44 (1H, brs), 9.25 (1H, s), 8.22 (1H, s), 7.54 (1H, dd, J=7.7, 1.4 Hz), 7.24 (1H, ddd, J=8.1, 7.4, 1.5 Hz), 7.10 (1H, dd, J=8.2, 1.2 Hz), 6.98 (1H, dt, Jd=1.3 Hz, Jt=7. 5 Hz), 6.52 (2H, brs), 6.41 (1H, s), 3.79 (3H, s).

المصدر