تفاعل #79027

معادلة التفاعل

4-bromo-2-fluoroanisole

(1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid

→

6-(3-Fluoro-4-methoxy-phenyl)4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one

ظروف التفاعل

المعالجة

1. 1
   أخرىPrepared

الإجراء التجريبي

Prepared according to procedure B from 4-bromo-2-fluoroanisole and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White solid: mp 210-211° C. 1H-NMR (DMSO-d6), δ 10.27(s, 1H), 7.52-7.60 (m, 3H), 7.45(d, 1H, J=8.6 Hz), 7.22 (t, 1H, J=8.9 Hz), 6.94 (d, 1H, J=8.8 Hz), 3.87 (s, 3H), 1.66 (s, 6H). MS [M−H]−m/z=300 Anal. Calc. For C17H16FNO3: C, 67.76; H, 5.35; N, 4.65. Found: C, 67.88; H, 5.39; N, 4.70.

المصدر