تفاعل #78755

معادلة التفاعل

3-phenoxyaniline

1,1,1-trifluoro-2,3-epoxypropane

→

3-[(N-3-phenoxy-phenyl)amino]-1,1,1-trifluoro-2-propanol

المردود 71.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىwas placed in a sealed tube
2. 2
   أخرىgiving a dark solution
3. 3
   درجة الحرارةThe stirred solution was heated 18 h
4. 4
   درجة الحرارةcooled
5. 5
   أخرىto give a dark oil
6. 6
   أخرىPurification by flash chromatography on silica gel eluting with dichloromethane

الإجراء التجريبي

EX-588B)A mixture of solid 3-phenoxyaniline (2.96 g, 16 mmol) and 1,1,1-trifluoro-2,3-epoxypropane (1.30 mL, 15.0 mmol) was placed in a sealed tube and heated to 100° C. giving a dark solution. The stirred solution was heated 18 h and cooled to give a dark oil. Purification by flash chromatography on silica gel eluting with dichloromethane gave 3.15 g (71%) of the desired 3-[(N-3-phenoxy-phenyl)amino]-1,1,1-trifluoro-2-propanol product as a colorless oil. Anal. calcd. for C15H14NO2F3-0.05 CH2Cl2: C, 59.92; H, 4.71; N, 4.64. Found: C, 59.92; H, 4.53; N, 4.73. HRMS calcd. 298.1055 [M+H]+, found: 298.1056.

المصدر