تفاعل #78732

معادلة التفاعل

CH2Cl2

N-{[(2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide

BrCN

→

title compound

المردود 71.0%

2-AMINO-5,7-DIMETHYL-3-(4-{2-[({[(4-METHYLPHENYL)SULFONYL]AMINO}CARBONYL)AMINO]ETHYL}PHENYL)-3H-IMIDAZO[4,5-b]PYRIDINE DI-HYDROCHLORIDE

المردود 71.0%

المذيبات

THF

water

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with brine
2. 2
   تجفيفThe organic layer was dried over MgSO4
3. 3
   ترشيحfiltered
4. 4
   تركيزAfter concentration in vacuo
5. 5
   أخرىthe residue was purified by preparative TLC (CH2Cl2/MeOH=10/1)

الإجراء التجريبي

To a stirred solution of N-{[(2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide (300 mg, 0.66 mmol) in THF (6 ml) was added a solution of BrCN (175 mg, 1.65 mmol) in water (2 ml). The resultant mixture was stirred at room temperature for 16 hours. The mixture was diluted with CH2Cl2 and washed with brine. The organic layer was dried over MgSO4 and filtered. After concentration in vacuo, the residue was purified by preparative TLC (CH2Cl2/MeOH=10/1) to afford 224 mg (71%) of the title compound.

المصدر