تفاعل #78685

ord-e9a0fedd15fc4cf6bf35d67e5e21545a

معادلة التفاعل

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1OC)n2C)c1ccccc1.Cl
1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride
CCCCCCCOC(=O)Cl
n-heptyl chloroformate
→
CCCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccc4)ccc3n2C)c(OC)c1
1-Methyl-2-[N-(4-n-heptyloxycarbonylamidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
المردود 68.0%

المتفاعلات

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1OC)n2C)c1ccccc1.Cl
1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride
CCCCCCCOC(=O)Cl
n-heptyl chloroformate
—
C37H46N6O6

الكواشف

لا شيء

المذيبات

CCO.ClCCl
dichloromethane ethanol

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-heptyl chloroformate. Yield: 68% of theory, C37H46N6O6 (670.8); Rf value: 0.56 (silica gel; dichloromethane/ethanol=9:1); EKA mass spectrum: (M+H)+=671; (M+H+Na)++=347.4.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06710055B2uspto-grants-2004_03