تفاعل #78361

معادلة التفاعل

3-(1-Thyminyl)propanoic acid methyl ester

hydrochloric acid

→

title compound

المردود 71.0%

3-(1-thyminyl)propanoic Acid

المردود 71.0%

المذيبات

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 10 minutes
2. 2
   استخلاصThe solution was extracted with ethyl acetate (10×25 mL)
3. 3
   استخلاصThe organic phase was extracted with saturated aqueous sodium chloride
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   أخرىevaporated to dryness in vacuo

الإجراء التجريبي

3-(1-Thyminyl)propanoic acid methyl ester (1 g, 0.0047 mol) was suspended in 2 M sodium hydroxide (15 mL), refluxed for 10 minutes. The pH was adjusted to 0.3 with conc. hydrochloric acid. The solution was extracted with ethyl acetate (10×25 mL). The organic phase was extracted with saturated aqueous sodium chloride, dried over magnesium sulfate, and evaporated to dryness in vacuo, to give the title compound as a white solid (0.66 g, 71%). M.p. 118-121° C. Anal. for C8H10N2O4, found (calc.) C: 48.38 (48.49) H: 5.09 (5.09) N: 13.93 (14.14). The compound showed satisfactory 1H and 13C-NMR spectra.

المصدر