تفاعل #78286

معادلة التفاعل

ammonium hydroxide

glycidyldiethylamine

→

1-amino-3-diethylamino-propan-2-ol

المردود 92.0%

ظروف التفاعل

المعالجة

1. 1
   workup.WAITroom temperature for 14 hours
2. 2
   أخرىThe resulting reaction mixture
3. 3
   أخرىwas evaporated
4. 4
   workup.DISTILLATIONdistilled (84-90° C. at 500-600 mT)

الإجراء التجريبي

To the ice-cold solution of ammonium hydroxide (25 mL, 159 mmole) of 25% (w/w) was added glycidyldiethylamine dropwise (3.2 g, 24.8 mmol) over 10 minutes. The reaction mixture was stirred at 0-5° C. for 1 hour and then room temperature for 14 hours. The resulting reaction mixture was evaporated and distilled (84-90° C. at 500-600 mT) to yield 1-amino-3-diethylamino-propan-2-ol (3.3 g, 92%). MS m/z 147 ([M+1]−).

المصدر