تفاعل #78285

معادلة التفاعل

sodium hydroxide

1-chloro-3-diethylamino-propan-2-ol

→

glycidyldiethylamine

المردود 76.0%

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ether twice
2. 2
   تجفيفThe combined ether solution was dried with solid potassium hydroxide
3. 3
   أخرىevaporated
4. 4
   أخرىto give 135 g of crude product which
5. 5
   workup.DISTILLATIONwas purified by fraction distillation

الإجراء التجريبي

A solution of sodium hydroxide (47.9 g, 1.2 mole) in 78 mL water was added 1-chloro-3-diethylamino-propan-2-ol. The resultant was stirred at 20-25° C. for 1 hour, diluted with 178 mL of water and extracted with ether twice. The combined ether solution was dried with solid potassium hydroxide and evaporated to give 135 g of crude product which was purified by fraction distillation to give pure glycidyldiethylamine (98 g, 76%) as an oil.

المصدر