تفاعل #78266

معادلة التفاعل

thionyl chloride

methyl 5-carboxy-1H-benzimidazole-2-carbamate

→

Methyl 5-chlorocarbonyl-1H-benzimidazole-2-carbamate

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux under argon for 3.5 hours
2. 2
   workup.DISTILLATIONthe solvent and excess thionyl chloride were distilled under reduced pressure
3. 3
   أخرىto remove all traces of thionyl chloride

الإجراء التجريبي

7.4 mL (12.069 g, 101.4 mmol) thionyl chloride and 1.80 g (7.66 mmol) methyl 5-carboxy-1H-benzimidazole-2-carbamate in 37 mL dry benzene were heated to reflux under argon for 3.5 hours. The mixture was then cooled to 23° C. and the solvent and excess thionyl chloride were distilled under reduced pressure. The resulting brown solid was stored under vacuum to remove all traces of thionyl chloride and used in the following Examples without further purification.

المصدر