تفاعل #78240

معادلة التفاعل

aluminum oxide

diethyl ether

1-benzylpiperidin-4-spiro-2′-oxirane

4-butoxy-N-methylaniline

→

titled compound

المردود 75.5%

1-benzyl-4-[N-(4-n-butoxyphenyl)-N-methylaminomethyl]piperidin-4-ol

المردود 75.5%

المذيبات

Methanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred at room temperature for 2 hours
2. 2
   ترشيحThe reaction solution was filtered
3. 3
   تركيزthe filtrate was concentrated under reduced pressure
4. 4
   أخرىThe residue obtained
5. 5
   أخرىwas purified by silica gel column chromatography (elution solvent; ethyl acetate)

الإجراء التجريبي

Activated neutral aluminum oxide 90 (activity I, made by Merck Co.) (5 g) was added to a diethyl ether solution (10 mL) of 1-benzylpiperidin-4-spiro-2′-oxirane (0.50 g) and 4-butoxy-N-methylaniline (0.53 g) and stirred at room temperature overnight. Methanol (20 mL) was added to the reaction solution and stirred at room temperature for 2 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography (elution solvent; ethyl acetate) to obtain the titled compound (0.71 g).

المصدر