تفاعل #78146

معادلة التفاعل

1-chloro-4-(4-pyridylmethyl)phthalazine

3-aminophenol

→

title compound

1-(3-Hydroxyanilino)-4-(4-pyridylmethyl)phthalazine

المذيبات

methanol

acetate

potassium carbonate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling to RT
2. 2
   ترشيحfiltration
3. 3
   غسيلwashing of the filter residue with methanol
4. 4
   أخرىdrying under HV (8 h, 130° C.)

الإجراء التجريبي

A mixture of 0.384 g (1.5 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine and 0.491 g (4.5 mmol) 3-aminophenol is heated under nitrogen atmosphere for 1 h at 90° C. and for 3 h at 120° C. The reaction mixture is then taken up in a mixture of 30 ml acetate and 20 ml 20% aqueous potassium carbonate solution while stirring for about 4 h, and the filtration material is digested for 20 min in 20 ml of boiling methanol. After cooling to RT, filtration, washing of the filter residue with methanol, and drying under HV (8 h, 130° C.), title compound is obtained with a water content of 1.94%; m.p. 217-219° C.; ESI-MS: (M+H)+=329.

المصدر