تفاعل #7810

معادلة التفاعل

2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole

NBS

benzoyl peroxide

→

2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole

المذيبات

CCl4

ظروف التفاعل

المعالجة

1. 1
   أخرىCCl4 was removed in vacuo and residue
2. 2
   أخرىwas purified by flash column (silica gel, hexanes:EtOAc 5:1)

الإجراء التجريبي

A solution of 2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole (200 mg, 0.74 mmol, 84%), NBS (179 mg, 0.81 mmol), and benzoyl peroxide (50 mg) in CCl4 (10 mL), was refluxed for 12 h. After cooling to rt, CCl4 was removed in vacuo and residue was purified by flash column (silica gel, hexanes:EtOAc 5:1) to afford 2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole. MS (ESI) 349 (M+H)+.

المصدر