تفاعل #78078

معادلة التفاعل

water

5-bromo-2,4-dichloropyrimidine

4-methoxyphenol

potassium carbonate

→

product

المردود 96.0%

5-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

المردود 96.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solid which separated out
2. 2
   ترشيحwas collected by filtration
3. 3
   غسيلwashed with water (50 ml)
4. 4
   أخرىdried under high vacuum

الإجراء التجريبي

A mixture of 5-bromo-2,4-dichloropyrimidine (5.0 g, 22.0 mmol), 4-methoxyphenol (2.72 g, 22.0 mmol) and potassium carbonate (6.07 g, 44.0 mmol) in DMF (20 ml) was stirred for 24 hours. The mixture was added to water (100 ml) and the solid which separated out was collected by filtration, washed with water (50 ml) and dried under high vacuum to give the product (6.6 g, 96%). NMR: 3.8 (s, 3H), 7.0 (d, 2H), 7.2 (d, 2H), 8.8 (s, 11H).

المصدر