تفاعل #78063

معادلة التفاعل

water

4-(4-fluorobenzoylamino)piperidine

pyridine

4-trifluoromethoxybenzoyl chloride

→

4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلThe separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine
2. 2
   تجفيفdried over magnesium sulfate
3. 3
   أخرىEvaporation of the solvent under reduced pressure

الإجراء التجريبي

To a solution of 4-(4-fluorobenzoylamino)piperidine (0.15 g) in dichloromethane (5 ml) were added in turn pyridine (82 μl) and 4-trifluoromethoxybenzoyl chloride (106 μ) at 0° C. The mixture was allowed to warm to ambient temperature and stirred for 4 hours, which was taken up into a mixture of water and dichloromethane. The separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine, and dried over magnesium sulfate. Evaporation of the solvent under reduced pressure gave 4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine (205 mg).

المصدر