تفاعل #78061

معادلة التفاعل

1-acetyl-4-aminopiperidine hydrochloride

4-fluorophenyl isocyanate

diisopropylethylamine

→

N-(1-acetylpiperidin-4-yl)-N′-(4-fluorophenyl)urea

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىAn organic phase was separated
2. 2
   استخلاصan aqueous phase was extracted with dichloromethane
3. 3
   تجفيفA combined organic phase was dried over magnesium sulfate
4. 4
   أخرىthe solvents were removed under reduced pressure
5. 5
   أخرىAfter crystallization from diisopropyl ether and n-hexane

الإجراء التجريبي

To a suspension of 1-acetyl-4-aminopiperidine hydrochloride (536 mg) in dichloromethane (5 ml) were added 4-fluorophenyl isocyanate (375 μl) and diisopropylethylamine (575 μl ) at ambient temperature. After stirring for 3 hours, the reaction mixture was diluted with dichloromethane. An organic phase was separated and an aqueous phase was extracted with dichloromethane. A combined organic phase was dried over magnesium sulfate and the solvents were removed under reduced pressure. After crystallization from diisopropyl ether and n-hexane, N-(1-acetylpiperidin-4-yl)-N′-(4-fluorophenyl)urea (448 mg) was obtained.

المصدر