تفاعل #77958

معادلة التفاعل

n-butyl nitrite

3-nitro-o-xylene

potassium tert-butoxide

hydrochloric acid

→

2-methyl-6-nitrobenzonitrile

المذيبات

dimethylformamide

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe aqueous phase is extracted with ethyl acetate
2. 2
   غسيلThe organic phase is washed with water
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   تركيزconcentrated
5. 5
   أخرىThe 2-methyl-6-nitrobenzonitrile can be purified by silica gel chromatography

الإجراء التجريبي

A solution of 16 g (150 mmol) of n-butyl nitrite (97% pure) and 7.7 g (50 mmol) of 3-nitro-o-xylene (97% pure) in 50 ml of dimethylformamide is cooled to from −5 to −10° C., and a solution of 11 g (100 mmol) of potassium tert-butoxide in 50 ml of dimethylformamide is added dropwise at this temperature, over a period of 1.5 hours. The reaction mixture is stirred at room temperature for another 6 days. For work-up, the mixture is poured into ice-water, the pH is adjusted to 1 using hydrochloric acid and the aqueous phase is extracted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate and concentrated. This gives 8.2 g of product. The 2-methyl-6-nitrobenzonitrile can be purified by silica gel chromatography using toluene as mobile phase. M.p.: 101-103° C.

المصدر