تفاعل #77955

معادلة التفاعل

water

n-butyl nitrite

N,N-diphenyl-2,3-dimethyl-4-methylsulfonylbenzamide

potassium tert-butoxide

→

N,N-diphenyl-3-hydroxyimino-2-methyl-4-methylsulfonylbenzamide

المذيبات

acetic acid

dimethylformamide

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe aqueous phase is extracted with ethyl acetate
2. 2
   غسيلThe organic phase is washed with sodium bicarbonate solution
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   تركيزconcentrated
5. 5
   أخرىThis gives 3.0 g of a partially crystalline crude product which is purified by silica gel chromatography

الإجراء التجريبي

A solution of 0.7 g (6.9 mmol) of n-butyl nitrite (97% pure) and 2 g (5.3 mmol) of N,N-diphenyl-2,3-dimethyl-4-methylsulfonylbenzamide in 30 ml of dimethylformamide is cooled to from −55 to −60° C., and a solution of 1.4 g (12 mmol) of potassium tert-butoxide in 10 ml of dimethylformamide is added dropwise at this temperature, over a period of 20 minutes. The reaction is monitored by HPLC. For work-up, initially 10 ml of water are added, and the pH is subsequently adjusted to 5-6 using glacial acetic acid. The reaction mixture is subsequently poured into 100 ml of ice-water, and the aqueous phase is extracted with ethyl acetate. The organic phase is washed with sodium bicarbonate solution, dried over magnesium sulfate and concentrated. This gives 3.0 g of a partially crystalline crude product which is purified by silica gel chromatography using toluene/acetone as mobile phase.

المصدر