تفاعل #77920

معادلة التفاعل

hydrochloric acid

Toluene

7-(2-naphthoyl)-3-methyl-5,6-dihydro-2(4H)-benzofuranone

acetic acid potassium salt

→

desired product

α-Methyl-3(2-naphthoyl)benzene Acetic Acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added to a reactor
2. 2
   درجة الحرارةThe reaction mixture was cooled down to room temperature
3. 3
   أخرىToluene layer separated
4. 4
   تجفيفwas dried over anhydrous MgSO4
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated
7. 7
   أخرىto give crude product
8. 8
   أخرىThe crude product was purified by column chromatograph on silica gel
9. 9
   غسيلby eluting with a mixture of ethylacetate and n-hexane (1:5)

الإجراء التجريبي

A mixture of 7-(2-naphthoyl)-3-methyl-5,6-dihydro-2(4H)-benzofuranone (10 g) and acetic acid potassium salt (0.3 g) was added to a reactor and stirred for 1 hr at 220° C. The reaction mixture was cooled down to room temperature. Toluene and water were added to the reaction mixture and acidified to pH 2 with 5% hydrochloric acid. Toluene layer separated was dried over anhydrous MgSO4, filtered and evaporated to give crude product. The crude product was purified by column chromatograph on silica gel by eluting with a mixture of ethylacetate and n-hexane (1:5) to give the desired product (9:42 g, 94 % .

المصدر