تفاعل #77570

معادلة التفاعل

1,4-bis(5-bromo-2-pyridyl)hexahydro-1,4-diazepine

4-trifluoromethylphenylboronic acid

→

title compound

المردود 40.6%

1,4-Bis[5-(4-trifluoromethylphenyl)-2-pyridyl]hexahydro-1,4-diazepine

المردود 40.6%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude crystals were recrystallized from chloroform-hexane

الإجراء التجريبي

Following the procedure of Example 1, crude crystals were obtained from the 1,4-bis(5-bromo-2-pyridyl)hexahydro-1,4-diazepine (206.0 mg, 0.500 mmol) synthesized in Reference Example 1 and 4-trifluoromethylphenylboronic acid (227.0 mg, 1.20 mmol). The crude crystals were recrystallized from chloroform-hexane to yield the title compound as colorless needles (melting point: 236.0-238.0° C.) (110.0 mg, yield: 40%).

المصدر