تفاعل #77332

معادلة التفاعل

[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol

→

5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde

المردود 86.1%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate was filtered through celite
2. 2
   غسيلwashing with hot dichloromethane
3. 3
   تركيزThe filtrate was concentrated

الإجراء التجريبي

Manganese oxide (3.75 g, 43.1 mmol) was added portionwise to [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol (660 mg, 2.53 mmol) dissolved in dichloromethane (68 mL) under nitrogen at room temperature. The precipitate was filtered through celite, washing with hot dichloromethane. The filtrate was concentrated to give 563 mg (83%) of 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde as a waxy brown solid.

المصدر