تفاعل #77307

معادلة التفاعل

1-(3,4-difluorophenyl)piperazine

8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione

→

title compound

المردود 40.2%

8-{2-[4-(3,4-Difluorophenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione

المردود 40.2%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   أخرىThe residue was purified by preparative HPLC (see Example 8 for conditions)
3. 3
   أخرىgiving (

الإجراء التجريبي

A mixture of 1-(3,4-difluorophenyl)piperazine (21.5 mg, 0.109 mmol) and 8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione(20 mg, 0.087 mmol) was heated with stirring at 165° C. for 1 hour. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (13.7 mg, 0.035 mmol, 40%): ESI-MS m/z 392 (MH+).

المصدر