تفاعل #7714

معادلة التفاعل

sodium iodide

4,6-dichloro-2-methylsulfanyl-pyrimidine

3-amino-5-methylpyrazole

diisopropylethylamine

→

[6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

المذيبات

BuOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent is then removed in vacuo
2. 2
   أخرىthe residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient)

الإجراء التجريبي

To a solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine (5 g, 25.6 mmol) and 3-amino-5-methylpyrazole 2.61 g, 26.9 mmol) in BuOH (60 mL) is added diisopropylethylamine (4.69 mL, 26.9 mmol) followed by sodium iodide (3.84 g, 25.6 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is then removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

المصدر