تفاعل #7701

معادلة التفاعل

(2-chloroquinazolin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine

benzylmagnesium chloride

→

(2-benzyl-quinazolin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction mixture is then quenched with aqueous NH4Cl
2. 2
   استخلاصthe product extracted in ethyl acetate
3. 3
   أخرىThe solvent is evaporated
4. 4
   أخرىthe residue purified by flash chromatography

الإجراء التجريبي

To a solution of the above-prepared (2-chloroquinazolin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine (123 mg, 0.43 mmol) in THF (5 mL) is added NiCl2(dppp) (12 mg, 2.1.10−5 mol), followed by 1M benzylmagnesium chloride in THF (2.15 mL, 2.15 mmol). The solution is heated at 50° C. for 20 hours and the reaction mixture is then quenched with aqueous NH4Cl and the product extracted in ethyl acetate. The solvent is evaporated and the residue purified by flash chromatography to yield the desired (2-benzyl-quinazolin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine.

المصدر