تفاعل #7697

معادلة التفاعل

2,4-dichloroquinazoline

3-amino-5-methylpyrazole

triethylamine

→

(2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe pale yellow precipitate is then collected by filtration
2. 2
   غسيلwashed with cold ethanol
3. 3
   أخرىdried under vacuum

الإجراء التجريبي

To a solution of 2,4-dichloroquinazoline (12.69 g, 63 mmol) and 3-amino-5-methylpyrazole (6.18 g, 63 mmol) in ethanol (220 mL) is added triethylamine (8.13 mL, 63 mmol) and the reaction mixture is stirred for 3 hours at room temperature. The pale yellow precipitate is then collected by filtration, washed with cold ethanol and dried under vacuum to give (2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

المصدر