تفاعل #7694

معادلة التفاعل

chloroacetonitrile

benzylpiperazine

→

N-benzyl-N′-cyanomethylpiperazine

المذيبات

THF

Et3N

ظروف التفاعل

المعالجة

1. 1
   أخرىbefore quenched with saturated aqueous NaHCO3 (100 ml)
2. 2
   استخلاصThe aqueous phase was extracted with EtOAc (3×100 ml)
3. 3
   تجفيفThe combined organic layer was dried over MgSO4
4. 4
   تركيزconcentrated to a residue, which
5. 5
   أخرىwas used in the further reactions without any purification

الإجراء التجريبي

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

المصدر