تفاعل #7689

معادلة التفاعل

4-fluorocinnamic acid

(S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine

EDC

triethylamine

→

title compound

المردود 60.4%

(S)-3-(4-Fluorophenyl)-N-{1-[3-(4-pyridin-2-ylpiperazin-1-yl)phenyl]ethyl}-acrylamide

المردود 60.4%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1)

الإجراء التجريبي

A solution of 4-fluorocinnamic acid (17 mg, 0.1 mmol), (S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine (24 mg, 0.11 mmol), EDC (28 mg, 0.15 mmol), DMAP (12 mg, 0.1 mmol) and triethylamine (40 mg, 0.4 mmol) in dichloromethane (2 ml) was stirred at room temperature for 14 h. The reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1) to give the title compound as a solid (26 mg, 60% yield).

المصدر