تفاعل #7685

ord-68fa38bc4e1d4b57ae1257ff098cfd25

معادلة التفاعل

CCc1nc(C2CCNCC2)n2nc(-c3ccccc3)[nH]c(=O)c12
5-ethyl-2-phenyl-7-(4-piperidinyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one
O=C(Cl)C1CCCC1
cyclopentanecarbonyl chloride
CCc1nc(C2CCN(C(=O)C3CCCC3)CC2)n2nc(-c3ccccc3)[nH]c(=O)c12
7-[1-(Cyclopentylcarbonyl)-4-piperidinyl]-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

In analogy to the procedure for Example 103 Step (b), 30 mg (0.09 mmol) 5-ethyl-2-phenyl-7-(4-piperidinyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one, 14 mg (0.10 mmol) cyclopentanecarbonyl chloride are stirred at room temperature overnight, proportionate amounts of the solvents are used.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07087605B2uspto-grants-2006_08