تفاعل #76816

معادلة التفاعل

Benzyl alcohol

(S)-3-(benzoylaminomethyl)-5-methylhexanoic acid

(S)-3-(Benzoylaminomethyl)-5-methylhexanoic Acid

1,3-dicyclo-hexylcarbodiimide

→

5

المردود 79.0%

(S)-Benzyl 3-(benzoylaminomethyl)-5-methylhexanoate

المردود 79.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   تركيزconcentrated in vacuo
3. 3
   أخرىThe residue was chromatographed (SiO2, heptane-ether, 1:0 to 75:25)

الإجراء التجريبي

Benzyl alcohol (0.31 g, 3.0 mmol) was added to a stirred mixture of (S)-3-(benzoylaminomethyl)-5-methylhexanoic acid 4 (0.78 g, 3.0 mmol), 1,3-dicyclo-hexylcarbodiimide (0.61 g, 3.0 mmol), and 4-dimethylaminopyridine (0.36 g, 3.0 mmol) in dichloromethane (40 ml) and the mixture was stirred for 18 hours. The reaction mixture was, filtered and concentrated in vacuo. The residue was chromatographed (SiO2, heptane-ether, 1:0 to 75:25) to give 5(0.83 g, 79%).

المصدر