تفاعل #76771

معادلة التفاعل

methyl 2-bromo-4-fluoro-5-nitrophenoxyformate

sodium hydroxide

→

2-bromo-4-fluoro-5-nitrophenol

المردود 100.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىAfter completion of the reaction
3. 3
   غسيلwashed with chloroform
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   تجفيفThe ethyl acetate layer was dried
6. 6
   تركيزconcentrated

الإجراء التجريبي

Then, 125 g (0.43 mol) of methyl 2-bromo-4-fluoro-5-nitrophenoxyformate was suspended in 200 ml of water, to which 19 g (0.47 mol) of sodium hydroxide was added, and the mixture was stirred at 50° to 60° C. for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and washed with chloroform. The aqueous layer was acidified with aqueous hydrochloric acid and extracted with ethyl acetate. The ethyl acetate layer was dried and concentrated, which afforded 104 g (0.43 mol) of 2-bromo-4-fluoro-5-nitrophenol.

المصدر