تفاعل #7670

معادلة التفاعل

N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2-methylcyclopropanecarboxamide

phosphoric trichloride

→

2-Cyclopentyl-5-ethyl-7-(2-methylcyclopropyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 4 hours
2. 2
   أخرىThe isomers are purified by chromatography (preparative HPLC)

الإجراء التجريبي

In analogy to the procedure for Example 1, 200 mg (0.66 mmol) crude N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2-methylcyclopropanecarboxamide, 165 mg (1.1 mmol) phosphoric trichloride are stirred at reflux for 4 hours, proportionate amounts of the solvents are used. The isomers are purified by chromatography (preparative HPLC).

المصدر