تفاعل #76562

معادلة التفاعل

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

المردود 92.2%

المذيبات

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 3 hours during which time a solution
3. 3
   أخرىwas obtained
4. 4
   ترشيحit was filtered
5. 5
   ترشيحthrough filter paper under vacuum
6. 6
   أخرىThe resulting precipitate was collected
7. 7
   غسيلwashed with water
8. 8
   أخرىdried

الإجراء التجريبي

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

المصدر