تفاعل #76400

معادلة التفاعل

2′,3′-difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid ethyl ester

2′,3′-Difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic Acid Ethyl Ester

potassium hydroxide

→

2′,3′-difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid

المذيبات

water ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىquenched with hydrochloric acid (5%)
2. 2
   ترشيحThe resulting white solid was filtered
3. 3
   غسيلwashed with water
4. 4
   أخرىdried under vacuum

الإجراء التجريبي

A solution of 2′,3′-difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid ethyl ester (13A) (1 equi.) and potassium hydroxide (3.5 equi.) in water-ethanol (1:1) (25 mL/mmole) was stirred at 80 C temperature for 2 h., cooled to room temperature, quenched with hydrochloric acid (5%). The resulting white solid was filtered, washed with water, and dried under vacuum to give 2′,3′-difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid (14 A) as a white solid (80%).

المصدر