تفاعل #76367

ord-5fea9a53770246ee989f9ac9adc592d9

معادلة التفاعل

Cc1ccc(C(=O)Cl)cc1
4-Methylbenzoyl chloride
O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
uridine
→
Cc1ccc(C(=O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)cc1
product
Cc1ccc(C(=O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)cc1
5′-O-(4-Methylbenzoyl)uridine

المتفاعلات

Cc1ccc(C(=O)Cl)cc1
4-Methylbenzoyl chloride
O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
uridine

الكواشف

لا شيء

المذيبات

c1ccncc1
pyridine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىthe volatile components are evaporated in vacuo
  2. 2
    أخرىThe residue is purified

الإجراء التجريبي

4-Methylbenzoyl chloride (10 mmol) is added to a solution of uridine (10 mmol) in 20 mL of pyridine. After no further progress occurs as observed by TLC, the volatile components are evaporated in vacuo. The residue is purified using flash chromatography to give the product as a colorless oil.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06702705B1uspto-grants-2004_03