تفاعل #76364

معادلة التفاعل

HCl

1,3-propanediol

tert-butyldimethylchlorosilane

imidazole

→

product

3-(tert-Butyldimethylsiloxy)-1-propanol

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ether (3×100 mL)
2. 2
   غسيلThe organic phases were washed with brine (100 mL)
3. 3
   تجفيفdried over anhydrous MgSO4
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe mixture was purified by flash chromatography

الإجراء التجريبي

A mixture of 1,3-propanediol (10 mmol), tert-butyldimethylchlorosilane (11 mmol), and imidazole (22 mmol) dissolved in 5 mL of DMF was stirred at room temperature for 16 hours. The mixture was poured into 0.1 M HCl (100 mL) and extracted with ether (3×100 mL). The organic phases were washed with brine (100 mL), dried over anhydrous MgSO4, and concentrated in vacuo. The mixture was purified by flash chromatography to give the product as a colorless oil.

المصدر