تفاعل #7627

معادلة التفاعل

acetylchloride

2,6-diamino-4-chloro-pyrimidine

cyclohexylisonitrile

acetaldehyde

→

1-acetyl-5-amino-7-chloro-3-cyclohexylamino-2-methyl-imidazo[1,2-a]pyrimidin-1-ium chloride

المذيبات

perchloric acid

ظروف التفاعل

الإجراء التجريبي

Example 25 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μL perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

المصدر