تفاعل #76214

معادلة التفاعل

2-bromo-3′,4′-dichloroacetophenone

sodium formate

→

title compound

المردود 42.0%

2-Hydroxy-3′,4′-dichloroacetophenone

المردود 42.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux
3. 3
   تركيزThe reaction mixture was concentrated
4. 4
   workup.ADDITIONpoured into water (1 L)
5. 5
   ترشيحThe precipitated solid was collected by filtration
6. 6
   غسيلwashed with water
7. 7
   تجفيفwith isopropyl ether, air-dried
8. 8
   أخرىfurther dried under reduced pressure at 40° C.

الإجراء التجريبي

A mixture of 2-bromo-3′,4′-dichloroacetophenone (78.0 g), sodium formate (68.0 g) and methanol (300 mL) was heated under reflux and stirred for 16 h. The reaction mixture was concentrated and poured into water (1 L). The precipitated solid was collected by filtration, washed with water and then with isopropyl ether, air-dried, and further dried under reduced pressure at 40° C. to give the title compound as crystals (25.0 g, 42%). Recrystallization from ethyl acetate-hexane gave pale-yellow prism crystals. melting point: 115-118° C.

المصدر