تفاعل #76210

معادلة التفاعل

2-bromo-4′-trifluoromethylacetophenone

sodium formate

→

title compound

المردود 80.1%

2-Hydroxy-4′-trifluoromethylacetophenone

المردود 80.1%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux
3. 3
   تركيزThe reaction mixture was concentrated
4. 4
   workup.ADDITIONpoured into water (500 mL)
5. 5
   ترشيحThe precipitated solid was collected by filtration
6. 6
   غسيلwashed with water
7. 7
   أخرىair-dried

الإجراء التجريبي

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

المصدر